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Description / Abstract
The Human Papillomavirus (HPV) encodes a cancer-causing protein, E7, that degrades a known tumor suppressor retinoblastoma (pRb). This project studied the role of polarity in high-risk HPV16 E7. Mutations were made to HPV16 E7 to test its functionality. It was observed that pRb degradation was diminished with a concomitant decrease in polarity.
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Download as a PDF: Honors Paper
File Size Small - 1.7 MB
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KeywordsHPV, Cancer, How HPV Causes Cancer
Degree AwardedB.S. in Biology
Awarding InstitutionPoint Loma Nazarene University
Committee MembersHeidi Woelbern, Michael Dorrell, Ariane Jansma
Periodical TitleArete: The PLNU Honors Journal
Peer Reviewed?No
Collections With This Resource
PLNU Undergraduate Honors Projects 2021-2025
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