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Description / Abstract
Kava is a tranquilizing beverage from the South Pacific Islands that contains lipophilic compounds called kavalactones. Ingestion of these compounds is known to produce sedative and anxiolytic effects; however, the mechanisms underlying these changes are not fully elucidated. In our research studies at Greenville University we have shown that administration of kavalactones enhanced neuromuscular excitation in C. elegans nematodes, demonstrated by epileptic-like convulsions and paralysis in a dose-responsive manner. This response suggests an increase in acetylcholine (ACh) transmission at the neuromuscular junction (NMJ). Based on the behavioral responses and our genetic analysis in C. elegans, we hypothesized that kavalactones may mediate ACh transmission through the inhibition of acetylcholinesterase (AChE) enzyme. We tested this hypothesis by evaluating the responses of C. elegans worms harboring loss-of-function mutations in certain AChE genes. The findings discussed in this thesis seem to support the hypothesis that kavalactones affect the excitatory (cholinergic) system via AChE.
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Keywordskavalactones, acetylcholine, acetylcholinesterase
Degree AwardedBachelor's of Science
Awarding InstitutionGreenville University
Peer Reviewed?No
Pages58
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